Like many other forms of cancer, Mesothelioma has different stages. The earliest stage is still curable since only one layer of the pleura is affected. Surgery is the number one option for patients with Stage I Mesothelioma. The doctor removes the part of the lining of the lungs or chest (in case of Pleural Mesothelioma) and the lining of the abdomen (in case of Peritoneal Mesothelioma). In Stage II Mesothelioma, surgery can still be executed although some lymph nodes may have already been infected by the malignant Mesothelioma cancer cells. The diaphragm may also be removed; in severe cases, the Mesothelioma patient has to sacrifice one of his lungs.

Chemotherapy is the use of anti-cancer drugs to kill the malignant cells. In treating Mesothelioma, the anti-cancer drugs are usually given to the patient through intravenous injection (within the vein). Oncologists are still studying the possibility of treating Mesothelioma through intracavitary chemotherapy (within the chest or abdomen). Some Mesothelioma patients also undergo Photodynamic therapy, a kind of cancer therapy that combines the use of drug (photosensitizer) with a specific kind of light. The photosensitizing agent when exposed to the light produce oxygen that destroys nearby malignant cancer cells. The drug is injected into the bloodstream and is absorbed by the cells.

In order to relieve the symptoms of Mesothelioma such as the pain in the chest or abdomen due to the build up of fluid, a physician drains the fluid by using a needle. The procedure is known as thoracentesis (removal of fluid in the chest) or paracentesis (removal of the fluid in the abdomen). To prevent further accumulation of the lubricating fluid in the membranes of the chest or abdomen, drugs are given through a tube in the affected organ.

Although the said treatments to Mesothelioma have been proven effective, chance of recovery and survival still depends on the size or extent of the cancer. Chances are higher when Mesothelioma is still in its early stages. Surgery is only advisable only up to the second stage of the Mesothelioma cancer wherein only one part or smaller portions of the membranes are affected. A patient diagnosed with stage IV Mesothelioma (diffuse Mesothelioma) has only about 4-24 months to live. Furthermore, the age of the patient and his general health condition is also crucial to his recovery. Older patients do not respond well to certain cancer treatments such as surgery because their tissues, organs and other body parts are more delicate.
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